semaglutide nash phase 3 essence Alimentary Pharmacology & Therapeutics | Pharmacology Journal A Placebo-Controlled Trial of Subcutaneous
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Phase 3 trials include a 4mg maintenance arm specifically because some individuals achieve excellent results at lower doses

N Engl J Med (2016) 375:183444

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A study assessing the pharmacokinetics of once-daily oral semaglutide for 10 days showed no apparent effect of hepatic impairment on semaglutide pharmacokinetics regardless of the severity of hepatic dysfunction (39)
