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What does this tell us

Anti-obesity medicines, based around incretin receptor agonists and their novel combination with other appetite regulatory targets, have weight reduction efficacy in this population, addressing obesity-related cardiometabolic complications while preserving skeletal muscle mass

We speculate that the mechanism for the additional fat loss is a concurrent increase in energy expenditure coming from the muscle

Nutrition and eating behavior in patients with chronic pain receiving long-term opioid therapy

Approved in 2022 for diabetes (brand Mounjaro), tirzepatide produced extraordinary results in weight loss up to ~22% in obese participants at the highest dose in a phase 3 trial ( [137] )