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1998;275(5 pt 1):G911G921

GLP1-R is a class B G protein-coupled receptor,25 and its expression has been reported in the cerebral cortex, especially the occipital and frontal lobes, hypothalamus, and thalamus, whereas lower levels are found in the caudate putamen, globus pallidus, and hippocampus.21 GLP-1 and its RA cross the bloodbrain barrier, with exendin-4 considered as one of the best based on the rate of brain influx, percentage of reaching the brain that accumulates in the brain parenchyma, and percentage of the systemic dose taken per gram of brain tissue.8 Small amounts of GLP-1 may also be produced by preproglucagon neurons, located in the nucleus tractus solitarii of the brainstem26,27 and projected to other brain regions, such as the nuclei of the hypothalamus, including the arcuate and paraventricular nuclei.28 In the case of diabetes or obesity-related IR, GLP-1 secretion in the brain29 and peripheries30 may be impaired, which may contribute to the pathogenic change in neurodegeneration and cognitive decline

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1 Compounded GLP-1s are also associated with poorer outcomes

Efficacy and safety of ITCA 650, a novel drug-device GLP-1 receptor agonist, in type 2 diabetes uncontrolled with oral antidiabetes drugs: the FREEDOM-1 Trial