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186 VarolCZvibelISpektorLMantelmacherFDVugmanMThurmTet al

International Journal of Environmental Research and Public Health

Sharon Barr, Executive Vice President, BioPharmaceuticals R&D at AstraZeneca, said: Building on the promising Phase I clinical data generated by Eccogene, we believe this oral GLP-1RA molecule could offer alternatives to current injectable therapies both as a potential monotherapy as well as in combination for cardiometabolic diseases such as type-2 diabetes, as well as for obesity

We assessed the quality of the studies with the risk of bias assessment tool for randomized controlled trials and the Risk of Bias in Non-randomized Studiesof Interventions (ROBINS-I) tool for nonrandomized trials

The STEP-HFpEF trial randomised 529 patients with obesity (BMI 30 kg/m 2 ), HFpEF (left ventricular ejection fraction [LVEF] 45%) and New York Heart Association (NYHA) Class II symptoms to once-weekly subcutaneous semaglutide 2.4 mg or placebo
