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The 12 mg dose in TRIUMPH-4 led to a 28.7% loss over 68 weeks, while tirzepatide in the SURMOUNT-1 trial produced approximately 22.5% loss over 72 weeks

doi: 10.1210/en.2003-0323 93 WangQLiLXuEWongVRhodesCBrubakerPet al

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PRC dysfunction can result in epigenetic instability, leading to the repression of neurogenesis or inappropriate activation of developmental genes, both of which can drastically affect cognitive abilities and behavior (Cheon et al., 2022

risk of hyperkalemia 5
