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Description
The enzyme dipeptidyl peptidase 4 (DPP-4) cleaves active GLP-1 (7-36) amide and (7-37) non-amide after secretion from the gut and brain, forming two GLP-1 metabolites 8,10,12,13

GLP-1 receptor agonists seem to have the unique ability to reduce these effects without completely blocking dopamine release

298 , R1098R1110 (2010)

Neurological and cognitive benefits GLP-1R is expressed throughout the brain

It should be a great alternative. Lillys Oral GLP-1, Orforglipron, Delivers Weight Loss of Up to an Average of 27.3 lbs in First of Two Pivotal Phase 3 Trials in Adults With Obesity
