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In a mouse model of the GLP-1R agonist semaglutide, researchers found that semaglutide administration led to a significant decrease in body weight in treated mice while attenuating the expected decrease in energy expenditure due to the decrease in weight [47]

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Despite preliminary evidence suggesting that KD is safe and effective in individual cases, the available data is not representative and remains insufficient

This peptide has become a major focus in metabolic research due to its potent effects on satiety signaling
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