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A large retrospective cohort study from Weill Cornell Medical College - examining 255 patients (92% women, mean age 64) with DXA scans before and after starting semaglutide or tirzepatide - found that GLP-1 receptor agonist use was associated with greater annualized total hip bone loss in patients without diabetes, while patients with diabetes showed bone loss more comparable to non-users

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GLP-1 receptor agonists multifaceted therapeutic properties extend their benefits to a wide range of pain disorders, including inflammatory, visceral, and neuropathic pain (41, 42)

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Some members report slow responses that disrupted their treatment timelines

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Blonde L, Belousova L, Fainberg U, Garcia-Hernandez PA, Jain SM, Kaltoft MS, et al

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Common GLP-1 Progress Patterns One common pattern is an early drop followed by a slower period

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