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NMR and X-ray crystallography studies indicate that the N-terminal regions preceding the conserved -helix of GLP-1 (His 7 -Thr 13 ), exendin-4 (His 1 -Thr 7 ), GIP (Tyr 1 -Ile 7 ), glucagon (His 7 -Thr 13 ), and other class B GPCR peptide ligands are flexible in solution as well as in membrane-bound and ligand-bound states (Braun et al., 1983

Osteoporosis was experimentally induced using a high-fat diet with streptozotocin in two studies, ovariectomy in two studies, and dexamethasone administration in one study

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