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Another study done with mice by Forst and colleagues, showed that binding of GLP-1 to the GLP-1 receptor in the myocardium leads to an increase in production of cAMP and activation of protein kinase A, which yields an increase in glucose uptake and the inotropic effects of the heart
In addition to LEP being a gene marker for obesity, its levels influence increased food intake and weight gain, and increased amounts of LEP aid in promoting a systemic inflammatory response [49]

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