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Thus, metabolic changes may be key players in many disorders, including depression [91, 92]

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While AMPK is expressed in all ovarian compartments across different species (cow, goat, ewe, sow, hen, rat) including women, deletion of the AMPK1 subunit specifically in oocytes of mice results in a 27% reduction in litter size (54), highlighting the importance of the AMPK complex to oocyte developmental competence and fertility