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Here are listed the most common side effects reported by patients on Adalimumab (Humira): Skin rash Fever Positive ANA titer Antibody development Infections (upper respiratory infections such as sinusitis) Injection site reaction Nervous system symptoms such as headache and torso pain Cardiovascular complications such as acute myocardial infarction, cardiac arrhythmia, chest pain, and palpitations High cholesterol Gastrointestinal issues such as abdominal pain Hypersensitivity reaction Back pain Alopecia Can Humira increase the risk of infections