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[76] [77] In a 72-week, phase IIIb open-label head-to-head trial of adults with obesity without diabetes, tirzepatide at the maximum tolerated dose produced greater mean weight loss than semaglutide and larger reductions in waist circumference, while gastrointestinal adverse events were the most common with both drugs

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[DOI] [PMC free article] [PubMed] [Google Scholar] 64.Rosen E.D., Spiegelman B.M