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Zepbound, developed by Eli Lilly and Co., is already approved as Mounjaro for improving blood sugar in adults with type 2 diabetes

Pharmacological inhibition or genetic reduction of DPP-4 activity preserves much higher circulating levels of intact GLP-1 [191,192], and this was demonstrated to potentiate the insulinotropic effect of GLP-1 in anesthetized pigs (eventually leading to the development of DPP-4 inhibitors for clinical use) [193]

LPS is a bacterial endotoxin reported to increase cytokine secretion in different cell types

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We then administered the GLP-1R agonist Sem during late pregnancy