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Further research into how GLP-1 receptors control VAT metabolism would also provide important insights into the influence of gut hormone-based therapies on weight changes

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Avoid excessive sugar and processed foods that create insulin-mediated hunger cycles independent of GLP-1 signaling

Overall, the effect of GLP-1RAs on muscle mass shows a high degree of heterogeneity in clinical trials: some studies report that lean body mass reduction accounts for 40% to 60% of total weight loss, while others indicate that the proportion of lean body mass reduction is approximately 15% or lower [50]