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Any rapid, significant weight loss, whether from GLP-1 medications, bariatric surgery, or aggressive dieting, can produce identical effects

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Science 334 252255

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9.79 (7.3213.10) vs

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Metformin reduces hepatic glucose production and improves peripheral insulin sensitivity

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1 Diarrhoea and constipation were also more common on retatrutide than on placebo

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