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it may lower the absolute rates (to the same extent in the two groups) but is unlikely to bias the rates on the relative scale

[DOI] [PubMed] [Google Scholar] 23.Hosokai Y., Nishio Y., Hirayama K., Takeda A., Ishioka T., Sawada Y., Suzuki K., Itoyama Y., Takahashi S., Fukuda H., et al

This step-by-step approach, called dose titration, helps make treatment easier to tolerate while still allowing the medication to work effectively

Phase 3 data will be pivotal

Among the individual components of the primary endpoint, there was a reduction in CV death of 51% (HR 0.49
