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To improve site-specific delivery, oral nanoformulations designed to release GLP-1RAs in the colon are under development [386, 387]

However, treatment of isolated porcine proximal tubular cells with GLP-1 reduced sodium re-absorption [768]

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Glucagon-like peptide 1 receptor agonists (GLP-1RAs) were originally developed to treat type 2 diabetes, but are becoming increasingly popular for the treatment of obesity because they are effective at helping people lose weight