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The role of gut hormones and the hypothalamus in appetite regulation

Animal reproduction studies suggest potential risk, though human data is absent

2024;27(11):e15406

Serious side effects need immediate attention, these include hypoglycemia, severe allergic reactions, pancreatitis, and gallbladder problems

It is notable that neither the GLP-1R antagonist exendin(939) nor the GRA REMD2.59 had any (major) effect on glucagon secretion at 1 mmol/l glucose, making it unlikely that glucagon secretion is under significant autocrine control by glucagon or GLP-1(736) [63, 64] from alpha cells
