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The combination of tirzepatide and metformin is most appropriate for specific patient populations where both medications' complementary mechanisms address clinical needs

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Genetic Engineering Approaches Genetic engineering approaches have also been employed to enhance the therapeutic potential of hMSC through the stable overexpression of Ex-4

The activation of the cGAS-STING pathway has been confirmed to mediate the progression of synovitis and joint destruction by promoting the migration and invasion of fibroblast-like synoviocytes (FLS) and the production of inflammatory factors [22, 46]