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FDA prescribing information for Zepbound (tirzepatide) notes that 47% of trial participants stopped tirzepatide because of GI side effects overall

Association between different GLP-1 receptor agonists and gastrointestinal adverse reactions: A real-world disproportionality study based on FDA adverse event reporting system database

Even at lower doses, meaningful blood pressure reductions were observed

(e.g., RTW, Atlas, Bain Capital Life Sciences) Biotech VCs determine what GLP-1 era 2.0 looks like, and founders should watch them closely because they create long-term infrastructure needs

The main adverse effects leading to drug discontinuation were gastrointestinal disorders