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Description
(A) Activation of SIRT by activator leads to deacetylation of Lys48 residues on LKB1
J Clin Investig 116(2):299302 Schroeder EB (2022) Management of type 2 diabetes: selecting amongst available Pharmacological agents
32 The lack of tolerance of polar residues at this position was supported by an experiment replacing Ala with Val and led to only a marginal reduction in biological activity (3-fold)
doi:10.3762/bjnano.12.77
These include GLP-1 medications like semaglutide and tirzepatide, when clinically appropriate
