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There were 93 patients with other optic nerve disorders in the semaglutide or tirzepatide group, and 54 patients with these disorders in the comparison group

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Within the immune system, they inhibit NF-B and NLRP3 inflammasome activation, promote antiinflammatory IL-10 release, and promote macrophages and microglia toward antiinflammatory phenotypes (109, 110) (Figure 3), which could indirectly reduce cross-seeding of A and -synuclein initiated in the gut

Clinical efficacy remains equivalent across both formulations
