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An extensive list of agents including thiazolidinediones, insulin-like growth factors, fibroblast growth factors, gastrin, glycogen synthase kinase-3 (GSK-3) inhibitors, protein kinase dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitors, gamma-aminobutyric acid, quinolones, sphingosine phosphate, oestrogens and phytoestrogens, polyphenols, flavonoids and other plant compounds has been reported to increase beta cell proliferation in vitro or in animal models, but specifically targeting these agents to pancreatic beta cells in vivo remains an unfulfilled therapeutic challenge [30]

Research design note: Studies investigating body composition changes should specify whether the primary endpoint is total weight, fat mass, lean mass, or waist circumference, as the compounds differ most clearly on total and adipose-specific outcomes

Glucagon-like peptide-1 class drugs show clear protective effects in parkinsons and alzheimers disease clinical trials: A revolution in the making

Furthermore, migraine poses a risk factor for headache development, and migraine-like headache being associated with lower likelihood of headache improvement and headache freedom after one year [31]