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[DOI] [PubMed] [Google Scholar] 23.Mechanisms of action and therapeutic application of glucagon-like-1

Weight loss and thyroid hormone requirements : Substantial weight loss achieved through GLP-1 therapy may alter thyroid hormone requirements

Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity

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Based on the strength of the clinical data, we expect Wegovy to be added to formularies with utilization management restrictions for prior authorization to prevent off-label use, shorter initial approval periods (e.g., six months approved initially) to ensure efficacy, and quantity limits to reduce stockpiling and waste