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N Engl J Med 375(19):18341844 [DOI] [PubMed] [Google Scholar] Marx N, Husain M, Lehrke M, Verma S, Sattar N (2022) GLP-1 receptor agonists for the reduction of atherosclerotic cardiovascular risk in patients with type 2 diabetes

2.4 Advanced glycation end products (AGEs) Advanced glycation end products (AGEs) are a critical driver of retinal damage in early-stage diabetic retinopathy (DR), particularly in non-proliferative diabetic retinopathy (NPDR) (69)

Through HDAC6 inhibition, the pathway promotes the removal of damaged cellular components, reducing oxidative stress and enhancing cellular repair mechanisms in retinal cells ( 2.2.3 Beyond the eye In renal tubular cells ( + -dependent deacetylase SIRT1, reducing mitochondrial dysfunction and oxidative stress by decreasing ROS production, thereby preventing apoptosis induced by lipotoxicity