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Retatrutides effects on insulin sensitivity may prove especially beneficial for this population, though individual monitoring remains important

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63 Although there are no studies in which the efficacy of SNRIs is assessed in patients with IBS, the AGA and the Rome Foundation recommend their use based on the beneficial effects of SNRIs in other pain indications

That is why alopecia was only added later, in February 2025, in section 6.2 (Postmarketing) of the FDA label