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Tirzepatide demonstrated significant reductions in NASH-related biomarkers and elevated adiponectin levels compared to placebo or dulaglutide in patients with T2DM, as evidenced in post hoc analyses

In addition to the well-known effects of GLP-1 and GLP-1 RA in improving insulin sensitivity and reducing body weight, at central levels, GLP-1 and GLP-1 RA might exert regulating effects on GhRH release, and on concomitant gonadotropin secretion, likely by activating the kisspeptin hypothalamic system, a key regulator of the pulsatile release of GnRH from GnRH neurons

The American Journal of Managed Care .

Patients were matched 1:1 using propensity scores to balance demographics, comorbidities, prior inflammatory bowel disease treatments, healthcare use, and baseline steroid exposure

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