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It can also be used in individuals who are overweight (body mass index of 27 kg/m2 or greater) with at least one weight-related risk factor such as Type 2 diabetes, high blood pressure, or high cholesterol

In the SURPASS-2 trial, which compared tirzepatide with semaglutide in patients with T2DM, a total of 13 deaths (0.7%) occurred

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In preclinical studies, cotadutide demonstrated a more pronounced loss of body weight, reduction in food intake, and superior improvement in glycemic parameters in rodents compared to a GLP-1 RA

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