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Initially developed to improve glycemic control, these agents are now recognized as important components of cardiovascular risk reduction strategies

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Key pathways, including Wnt/-catenin, bone morphogenetic protein 2/Smad, phosphoinositide 3-kinase/Akt and protein kinase A, play a role in this

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In patients with eGFR>60 ml/min/1.73 m2 the changes of arterial pressure were comparable, while the morning surge was significantly reduced after liraglutide compared to placebo
