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The therapeutic approach to target the incretin system for the treatment of type 2 diabetes involves the use of GLP-1 agonists or DPP-4 inhibitors to increase the levels of endogenous GLP-1 ( In addition to pancreatic localization, GLP-1R has been found in the gastrointestinal system, kidneys, central nervous system, and cardiovascular system (Pyke et al., 2014)

Comparative trials show that long-acting medications (exenatide once weekly, liraglutide, dulaglutide, and semaglutide) provide better glycemic control than short-acting medications (exenatide twice daily and lixisenatide) [90]