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Long-term structural outcomes, including cartilage preservation and delayed joint replacement risk, still require further study

A SURMOUNT post-hoc analysis of 2,542 women found perimenopausal women on tirzepatide lost 23% of body weight vs 3% on placebo, nearly identical to the 26% loss in premenopausal women

Administration of an acylated GLP-1 and GIP preparation provides added beneficial glucose-lowering and insulinotropic actions over single incretins in mice with Type 2 diabetes and obesity

GLP-1 receptor agonists are administered subcutaneously into the abdomen, thigh, or upper arm with no clinically relevant absorption differences between sites

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