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Semaglutide (Ozempic, Wegovy): Clinicians use Ozempic to treat diabetes, and Wegovy for weight loss

Research Applications: Multi-receptor signaling pathway modeling (GLP-1, GIP, glucagon frameworks)

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doi: 10.1016/S0140-6736(23)01233-3 [DOI] [PubMed] [Google Scholar] 95.Thethi TK, Pratley R, Meier JJ

Although GLP-1RAs exert beneficial effects by delaying gastric emptying, enhancing satiety, and reducing caloric intakemechanisms that predominantly promote FM reductionthey are also associated with a loss of lean mass, particularly in the context of substantial weight loss where muscle preservation is critical for metabolic health [77]