contraindications for glp-1 agonists include Benefits and Risks of Receptor Outlined Glucagon-like Receptor-1 agonists for obesity:
Description
Yes, but mildly expect 3-5lb loss versus 15-20lb with prescription drugs

This dual action is one reason tirzepatide may support stronger results for some patients compared with GLP-1 treatment alone
doi: 10.33549/physiolres.933831 95 NiXRSunZJHuGHWangRH
doi: 10.1016/j.ejphar.2009.12.023 115 CastellanaMCignarelliABresciaFPerriniSNatalicchioALaviolaLet al

It functions as a dual GLP-1/GIP receptor agonist, meaning it targets two metabolic pathways
