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Description
March ushered in the first wave of off-patent competition for semaglutide, the active ingredient in Ozempic and Wegovy, marking a global turning point in metabolic medicine

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Trial Registration: UMIN Clinical Trials Registry (UMIN-CTR), UMIN000059813, retrospectively registered on November 18, 2025.

Background: Tirzepatide (LY3298176) was approved by U.S