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Phase 1 Trials In a first-in-human, randomized, placebo-controlled, single ascending dose, phase 1 trial in healthy participants, retatrutide demonstrated a favourable safety profile (similar to other incretin-based therapies) and early signs of efficacy with dose-dependent WL [42]

Avoid drinking large amounts at once as this can sometimes make nausea worse

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The Lancet Diabetes & Endocrinology , 2017;5(5):355-366

These could include: Digestive issues & feeling sick, especially when first starting Possible constipation or diarrhoea Some people experience fatigue Potential risk of thyroid tumors (rare) 2