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The crystal structure of ligand coupled to GLP-1R and GIPR extracellular domain (19-21), structure-activity relationships of incretins (10, 24, 25), the similarities in their primary sequences as well as the sequence differences in the middle and the C terminal region of the respective agonists, guided us to rationally design the hybrid peptide with potent GLP-1R and GIPR dual activity in a single molecule

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That is a substantial rate for a side effect that neither semaglutide nor tirzepatide produces at any meaningful frequency

Animal models: Not required at this stage for target-level questions