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Notably, improving diet and lifestyle or pharmacotherapy may be the options for treating obesity, but these methods may not have the desired anti-obese effect

20 Additionally, estrogen-mediated pelvic adiposity in women leads to a prothrombotic state and further weight gain

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This first part of TM5 is also involved in glucagon affinity in GCGR, with several mutations showing some effect on binding (Siu et al., 2013)

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