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Freezing causes ice crystals to form within the solution, which physically damages the peptide structure

One cohort study published in JAMA in November 2025 found that those who halted GLP-1 use before or early in their pregnancies gained more weight and had higher risks of pregnancy complications like hypertensive disorders, diabetes and preterm delivery compared to those who hadnt used the medications before

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Yuan Y, Isasi CR, Al-Rousan T, et al
