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SGLT2 inhibitors are preferred in people with HF or at high-risk for HF, whereas GLP-1 receptor agonists are favored for those requiring significant weight loss, ASCVD risk reduction, CKD management, or in whom mitigation of metabolic dysfunction-associated steatotic liver disease (MASLD) or steatohepatitis is a clinical priority [84]

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they are contraindicated in patients with personal or family history of medullary thyroid carcinoma or MEN 2 Potential risk of pancreatitis Gallbladder-related issues Hypoglycemia risk (particularly if combined with certain diabetes medications) Potential impacts on fertility and pregnancy This is not a complete list

[DOI] [PMC free article] [PubMed] [Google Scholar] 92.Pontzer H, Yamada Y, Sagayama H, Ainslie PN, Andersen LF, Anderson LJ, et al