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Mounjaro (Zepbound) Originally approved by the FDA for treating type 2 diabetes, Mounjaro (Zepbound) has been used off-label for weight loss

Acknowledgements Writing support was provided by Debbie Day of Axis, a division of Spirit Medical Communications Group Limited, supported by Novo Nordisk A/S in accordance with Good Publication Practice (GPP3) guidelines ( The authors would like to thank all the participants, investigators and trial-site staff who were involved in the conduct of the trials, Michael Pilgaard Andersen (Novo Nordisk A/S) for support with the bioanalyses and Christin Lth Hertz (Novo Nordisk A/S) for reviewing the manuscript

Patients sometimes assume that a more complex mechanism automatically means a medicine is better

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However, any dose reduction should happen gradually (over weeks to months) with close monitoring to ensure weight doesnt creep back up