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The Light Exposure Liability: Peptides, especially those containing certain amino acids like tryptophan or tyrosine, are sensitive to light, particularly UV light

together, these modifications extend the elimination half-life to ~160 h and allow once-weekly dosing [22, 23]

In contrast, the mean relative risk reduction in studies involving individuals with T2D, where weight loss was between 2% and 5%, was 15%, as seen in the aforementioned trials (48, 57, 59, 71)

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Phase 2 (Jastreboff et al., NEJM 2023) reported 24.2% weight loss at 48 weeks at 12 mg