glp-1 causing migraines Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation | The Journal of Headache and Pain GLP-1 medications and how they

In MS, peripherally activated T cells cross the blood-brain barrier (BBB) into the CNS, where they are re-activated and secrete cytokines to exert their effector functions [196]

Additionally, a multi-country study found substantial demand for GLP-1 medications among people without medical indications, highlighting the evolving landscape of body image and obesity treatment (Jensen et al., 2025)

High glucose levels and Gs-coupled receptor stimulation synergistically triggered insulin and GLP-1 secretion

And work in lab animals has sparked concerns about developing thyroid cancer, though more recent research suggests that this isnt likely in people

Thieu VT, Robinson S, KennedyMartin T, Boye KS, GarciaPerez LE