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Reconstituted peptide solutions are inherently less stable than lyophilized powder because water enables the chemical reactions (hydrolysis, deamidation) that drive degradation

For background on how retatrutide works, see our mechanism of action guide

It is a dual agonist that activates both the GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors

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Recent studies with long-acting glucagon-like peptide-1 (GLP-1) receptor agonists demonstrated greater efficacy with acceptable safety could be achieved by targeting the pathways of endogenous nutrient-stimulated hormones