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137 Use is also contraindicated in individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia

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doi: 10.1186/s13195-021-00813-8 [DOI] [PMC free article] [PubMed] [Google Scholar] 33

GLP-1R triggers various intracellular signaling pathways, such as the cAMP/PKA and PI3K/Akt pathways, by binding to endogenous GLP-1 or exogenous agonists, resulting in the enhancement of insulin secretion, inhibition of glucagon secretion, as well as anti-inflammatory and antioxidant stress response