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Cryo-EM images were collected on a Titan Krios microscope (FEI) equipped with Gatan energy filter and K3 direct electron detector and performed using serialEM

After 8 weeks of treatment, tirzepatide significantly reduced fasting plasma glucose levels, HbA1c levels (a measure of long-term blood sugar control), and body weight compared to the placebo

This creates a balancing act: you want a dose high enough to be effective, but well-tolerated enough to stay on long term

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GLP-1 receptor agonists like semaglutide work best when combined with healthy lifestyle changes