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A relevant issue that remains controversial is whether the positive impact of GLP-1RAs on hepatic histology is indirect, i.e., through their action on the pancreas or other extrahepatic tissues, or direct, i.e., through activating GLP-1R on hepatocytes

In-person visits, more frequent follow-ups, or adjunct prescriptions push you toward the higher end

Methods Protocol and registration The present systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to ensure methodological rigor and transparency

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This isn't just inflation or trend, its a convergence of cost drivers - : 74% spike in $1M+ claims since 2021 - : providers are charging more : quietly adding 24% to premiums : GLP-1s and specialty drugs are reshaping budgets : demand is up, longer treatments, higher costs