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Bottom line GERD and hiatus hernia are not contraindications to GLP-1RAs or tirzepatide

Liraglutide, a GLP1 analog, has showed to delay memory decline in a mouse model of AD (Hansen et al., 2015)

The phase 3 ESSENCE trial of semaglutide for MASH read out positively and FDA filing is in progress

Algarni MA, Algarni AAM, Alqarni WA, Alqassim AY (2023) Knowledge and Attitude of the General Population in Saudi Arabia Toward Weight Management Medications (WMMs): A Cross-Sectional Study

Nausea Burping or mild reflux Fullness or heavy stomach sensation Constipation Occasional looser stools You can help manage these by eating smaller portions, avoiding heavy or greasy meals, drinking water steadily, and taking light walks after eating