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doi: 10.1080/14656566.2019.1688784 45 HellstromPWebbD-L

Therefore, this study focuses on designing semaglutide analogues with site-specific missense mutations, and aims to strengthen GLP-1R activation through enhanced GLP-1R ECD binding affinity [26], contributing to the development of next-generation GLP-1R agonists with improved efficacy and specificity

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The most common GI side effects reported were [15]: Nausea (44.2%) Diarrhea (31.5%) Vomiting (24.8%) Constipation (23.4%) Dyspepsia (10.3%) Abdominal pain (10.0%) The trial also reported potentially serious side effects that may occur due to the inhibitory effect of GLP-1 on cholecystokinin synthesis and gallbladder motility, which delays gallbladder emptying [56]