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Most studies adopting similar ABX recipes did not observe any change in locomotion 20,21,22 , except for one study that showed increased locomotion 18 and another study that showed the opposite trend 19

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Moreover, while our MR analysis found no genetic evidence supporting a causal protective effect of metformin or semaglutide on AD, this does not rule out non-genetic mechanisms, such as metformins antiviral properties or microbiota modulation, which are not captured by MR analysis

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